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B.S., California Polytechnic State University at San Luis Obispo 1983
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M.S., Cornell University, NY 1985
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Ph.D., Cornell University, NY 1989
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Postdoctoral, Rutgers University, Piscataway, NJ 1993
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Postdoctoral, Schering Plough Research Institute, Kenilworth, NJ 1995
PUBLICATIONS
Research
Our laboratory is interested in determining the three-dimensional structures of small proteins in solution by multidimensional multinuclear nuclear magnetic resonance (NMR) spectroscopy. Current projects underway in the laboratory focus on relating structure to function and specificity in the Grb7 protein family. Members of this protein family have all been implicated in an increased occurrence of cancer. Specifically, Grb7 expression is up-regulated in 20-30% of breast cancers and these patients have a poor long-term survival rate. Our research is focused on unraveling the structural basis for the propensity of this protein family to bind only to specific up-stream and down-stream signaling partners. Study in this field spans a wide breadth of experimental approaches, including molecular biology, expression, and purification of proteins of interest, knowledge and implementation of data acquisition techniques using the NMR spectrometer, extensive data analysis and interpretation using available software on Unix based computers, and calculation and refinement of three-dimensional structures derived from NOE distance constraints.
